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Article

Integrin αvβ1 Is an Adenovirus Coreceptor

1 Jun 2001

Abstract excerpt

The human embryonic kidney (HEK293) cell line, commonly used for recombinant adenovirus (Ad) propagation, does not express the Ad coreceptor alpha(v)beta3 or alpha(v)beta5 integrins, yet these cells are efficiently infected by Ad vectors. Here we demonstrate that Ad binds to HEK293 cells via the fiber receptor CAR and is subsequently internalized via interaction with integrin alpha(v)beta1. Function-blocking...

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PMID: 11333925
DOI: 10.1128/jvi.75.11.5405-5409.2001

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