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Article

Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer.

Cancer research - 15 Aug 2003

Frazier Marsha L, Xi Lixuan, Zong Jihong, Viscofsky Nancy, Rashid Asif, Wu Elsie F, Lynch Patrick M, Amos Christopher I, Issa Jean-Pierre J

Abstract excerpt

Methylation of promoter CpG islands in colorectal cancer (CRC) falls into two categories: age related and cancer specific. Most cancer-specific methylation at CpG islands occurs in a subset of cases that display the CpG island methylator phenotype (CIMP). The underlying cause of CIMP is not known. Using methylation-specific PCR, we studied 47 CRC patients for methylation at five loci to determine whether the...

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PMID: 12941799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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