Article
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis.
Cell - 17 May 1991
Mucenski M L, McLain K, Kier A B, Swerdlow S H, Schreiner C M, Miller T A, Pietryga D W, Scott W J, Potter S S
Abstract excerpt
The c-myb proto-oncogene encodes a sequence-specific DNA-binding protein. To better understand its normal biological function, we have altered the c-myb gene by homologous recombination in mouse embryonic stem cells. Resulting homozygous c-myb mutant mice displayed an interesting phenotype. At da...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cell Line
- Chimera
- DNA
- DNA-Binding Proteins
- Erythropoiesis
- Fetus
- Globins
- Hematopoiesis
- Heterozygote
- Homozygote
- Liver
- Mice
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes