Article
Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear.
Developmental biology - 1 Sept 2003
Stevens Craig B, Davies Alex L, Battista Sarah, Lewis Julian H, Fekete Donna M
Abstract excerpt
Components of the Wnt signaling pathway are expressed in the developing inner ear. To explore their role in ear patterning, we used retroviral gene transfer to force the expression of an activated form of beta-catenin that should constitutively activate targets of the canonical Wnt signaling pathway. At embryonic day 9 (E9) and beyond, morphological defects were apparent in the otic capsule and the membranous...
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