Article
Interaction between smoking, GSTM1 deletion and colorectal cancer: results from the GSEC study.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jan 2000
Smits K M, Gaspari L, Weijenberg M P, Dolzan V, Golka K, Roemer H C, Nedelcheva Kristensen V, Lechner M C, Mehling G I, Seidegard J, Strange R C, Taioli E
Abstract excerpt
Cigarette smoking has inconsistently been associated with an increased risk of colorectal cancer. One of the enzymes responsible for the detoxification of the carcinogenic compounds present in tobacco smoke is glutathione S-transferase-mu (GST-mu). The gene that codes for this enzyme is GSTM1. In this study, we evaluated the associations and interaction between GSTM1 deletion, smoking behaviour and the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.