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Article

Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency.

Scientific reports - 30 Nov 2016

Sutherland Katherine A, Collier Dami A, Claiborne Daniel T, Prince Jessica L, Deymier Martin J, Goldstein Richard A, Hunter Eric, Gupta Ravindra K

Abstract excerpt

The gag gene is highly polymorphic across HIV-1 subtypes and contributes to susceptibility to protease inhibitors (PI), a critical class of antiretrovirals that will be used in up to 2 million individuals as second-line therapy in sub Saharan Africa by 2020. Given subtype C represents around half of all HIV-1 infections globally, we examined PI susceptibility in subtype C viruses from treatment-naïve individuals....

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Share to Darunavir
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to gag Gene Products, Human Immunodeficiency Virus

Share to HIV Protease Inhibitors

Share to Lopinavir

Share to Virus Replication

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Source

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Identifiers

PMID: 27901085
DOI: 10.1038/srep38153
PMCID: PMC5128871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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