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Article

Somatic cell genetics for the study of NF-kappaB signaling in innate immunity.

Science signaling - 30 Sept 2008

Krumbach Rebekka, Bloor Stuart, Ryzhakov Grigory, Randow Felix

Abstract excerpt

Vertebrates have evolved acquired immunity, but to detect an infection in its early stages they, nonetheless, rely on Toll-like receptors (TLRs) and other innate immune receptors. We have performed genomewide mutagenesis screens in an immortalized murine cell line to study nuclear factor kappaBeta (NF-kappaB) signaling in the context of innate immunity. To enable metabolic and physical selection for alterations...

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Identifiers

PMID: 18827221
DOI: 10.1126/scisignal.139pt7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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