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Article

Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass.

The Journal of clinical investigation - 1 Aug 2003

Ristow Michael, Mulder Hindrik, Pomplun Doreen, Schulz Tim J, Müller-Schmehl Katrin, Krause Anja, Fex Malin, Puccio Helene, Müller Jörg, Isken Frank, Spranger Joachim, Müller-Wieland Dirk, Magnuson Mark A, Möhlig Matthias, Koenig Michel, Pfeiffer Andreas F H

Abstract excerpt

Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing beta cells. We have disrupted expression of the mitochondrial protein frataxin selectively in pancreatic beta cells. Mice were born healthy but subsequently developed impaired glucose tolerance progres...

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Identifiers

PMID: 12925693
DOI: 10.1172/JCI18107
PMCID: PMC171391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12925693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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