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Article

PANIC-ATTAC: A Mouse Model for Inducible and Reversible β-Cell Ablation

9 May 2008

Abstract excerpt

OBJECTIVE: Islet transplantations have been performed clinically, but their practical applications are limited. An extensive effort has been made toward the identification of pancreatic beta-cell stem cells that has yielded many insights to date, yet targeted reconstitution of beta-cell mass remains elusive. Here, we present a mouse model for inducible and reversible ablation of pancreatic beta-cells named the...

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PMID: 18469203
DOI: 10.2337/db07-1631

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