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Article

Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2001

Poltoratsky V, Woo C J, Tippin B, Martin A, Goodman M F, Scharff M D

Abstract excerpt

High affinity antibodies are generated in mice and humans by means of somatic hypermutation (SHM) of variable (V) regions of Ig genes. Mutations with rates of 10(-5)--10(-3) per base pair per generation, about 10(6)-fold above normal, are targeted primarily at V-region hot spots by unknown mechanisms. We have measured mRNA expression of DNA polymerases iota, eta, and zeta by using cultured Burkitt's lymphoma...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11427727
DOI: 10.1073/pnas.141222198
PMCID: PMC35453

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Source receipt: pubmed, retrieved 7 Sept 2026.

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