Article
Genetic susceptibility to Parkinson's disease.
Geriatrics - 1 Aug 1991
Johnson W G
Abstract excerpt
Genetic factors clearly cause Lewy-body Parkinson's disease (PD) in a subset of autosomal-dominant families. However, most cases of PD are sporadic. The two most likely models of four discussed for sporadic PD are the reduced penetrance model and the multifactorial model. Sporadic PD is likely to be caused by the combined effect of environmental precipitating factors and genetic susceptibility factors. Because...
Topics
- Diseases in Twins
- Environment
- Genetic Predisposition to Disease
- Humans
- Models, Genetic
- Models, Neurological
- Mutation
- Parkinson Disease
- Twins