Article
Genotype-phenotype correlation: familial Parkinson disease.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Mar 2003
Mori Hideo, Hattori Nobutaka, Mizuno Yoshikuni
Abstract excerpt
Kindreds with Mendelian inheritance of Parkinson disease (PD) have been known since a long time ago. Nine loci have been mapped in familial PD by linkage study and four causative genes have been cloned. This paper discusses Park 1 and Park 2, the identification of which has brought about many advances in the studies on pathomechanism of PD. Investigations of these genes in familial PD have expanded their clinical...
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