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Article

Haplotype analysis of the prostacyclin synthase gene and essential hypertension.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jul 2003

Nakayama Tomohiro, Soma Masayoshi, Haketa Akira, Aoi Noriko, Kosuge Kotoko, Sato Mikano, Kanmatsuse Katsuo, Kokubun Shinichiro

Abstract excerpt

Previously, we discovered 3 polymorphisms in the prostacyclin synthase (PGIS) gene: 1) T-192G, in the 5-flanking region, a novel single-nucleotide polymorphism (SNP) that is not associated with essential hypertension (EH); 2) a variable number of tandem repeat (VNTR) polymorphism, 6 nucleotides upstream from the ATG start codon, that is associated with risk of cerebral infarction; and 3) C1117A, in exon 8, an SNP...

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PMID: 12924623
DOI: 10.1291/hypres.26.553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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