Article
Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension.
Biochemical and biophysical research communications - 11 Oct 2002
Nakayama Tomohiro, Soma Masayoshi, Watanabe Yoshiyasu, Hasimu Buaijiaer, Sato Mikano, Aoi Noriko, Kosuge Kotoko, Kanmatsuse Katsuo, Kokubun Shinichiro, Marrow Jason D, Oates John A
Abstract excerpt
Prostacyclin inhibits platelet aggregation, smooth muscle cell proliferation, and vasoconstriction. The prostacyclin synthase (PGIS) gene is a candidate gene for cardiovascular disease. The purpose of this study was to locate possible mutations in the PGIS gene related to hypertension and cerebral infarction. Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.