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Article

Polymorphism of the promoter region of prostacyclin synthase gene is not related to essential hypertension.

American journal of hypertension - 1 May 2001

Nakayama T, Soma M, Takahashi Y, Rehemudula D, Tobe H, Sato M, Uwabo J, Kunimoto M, Izumi Y, Kanmatsuse K

Abstract excerpt

An impaired synthesis of prostacyclin has been implicated in the development of essential hypertension (EH). We therefore investigated whether there is an association between the prostacyclin synthase (PGIS) gene and EH using a variable number of tandem repeats (VNTR) polymorphism in the promoter region that influences transcriptional activity of this gene. A total of 125 patients with EH and 125 age-matched...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11368458
DOI: 10.1016/s0895-7061(00)01256-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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