Article
Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jan 2002
Nakayama Tomohiro, Soma Masayoshi, Rahmutula Dolkun, Tobe Hideko, Sato Mikano, Uwabo Jiro, Aoi Noriko, Kosuge Kotoko, Kunimoto Masako, Kanmatsuse Katsuo, Kokubun Shinichiro
Abstract excerpt
The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5'-flanking region. We performed an association study using the SNP in 200...
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