Article
Analysis of an interleukin-6 gene promoter polymorphism in women with endometriosis by pyrosequencing.
Journal of the Society for Gynecologic Investigation - 1 Jan 2003
Wieser Fritz, Fabjani Gerhild, Tempfer Clemens, Schneeberger Christian, Sator Michael, Huber Johannes, Wenzl Rene
Abstract excerpt
Interleukin (IL)-6 has been implicated in the etiology of endometriosis. A single nucleotide polymorphism (SNP) at position -174 in the IL-6 gene promoter appears to influence IL-6 transcription rates in vitro and basal IL-6 levels in vivo. We determined the genotype and the allele frequencies of the -174 IL-6 promoter polymorphism and the corresponding IL-6 serum levels in women with endometriosis. The...
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