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Article

Solution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactions.

PloS one - 1 Jan 2012

Bhati Mugdha, Lee Christopher, Gadd Morgan S, Jeffries Cy M, Kwan Ann, Whitten Andrew E, Trewhella Jill, Mackay Joel P, Matthews Jacqueline M

Abstract excerpt

Lhx3 is a LIM-homeodomain (LIM-HD) transcription factor that regulates neural cell subtype specification and pituitary development in vertebrates, and mutations in this protein cause combined pituitary hormone deficiency syndrome (CPHDS). The recently published structures of Lhx3 in complex with each of two key protein partners, Isl1 and Ldb1, provide an opportunity to understand the effect of mutations and...

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Source

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Identifiers

PMID: 22848397
DOI: 10.1371/journal.pone.0040719
PMCID: PMC3405102

Genes

LIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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