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Article

Stat1-mediated cytoplasmic attenuation in osteoimmunology

15 Nov 2004

Abstract excerpt

Signal transducer and activator of transcription 1 (Stat1) is a critical mediator of gene transcription in type I interferon (IFN-alpha/beta) signaling that is essential for host defense against viruses. In the skeletal system, type I IFNs (IFN-alpha/beta) also play an important physiological role in the inhibition of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation and bone...

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PMID: 15546140
DOI: 10.1002/jcb.20316

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