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Article

A metabolic model for life span determination in Caenorhabditis elegans.

Developmental cell - 1 Aug 2003

Rea Shane, Johnson Thomas E

Abstract excerpt

Several studies with the nematode Caenorhabditis elegans have made the unexpected discovery that certain hypomorphic mutations in genes encoding mitochondrial proteins result in life span extension. These mutations appear to act independently of the other known pathway that regulates life span extension, the dauer-specifying insulin/IGF-1-like pathway. Here we present a hypothesis that unifies the effects of...

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PMID: 12919672
DOI: 10.1016/s1534-5807(03)00242-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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