Article
Placing mitochondrial DNA mutations within the progression model of type I endometrial carcinoma.
Human molecular genetics - 15 Jun 2011
Guerra Flora, Kurelac Ivana, Cormio Antonella, Zuntini Roberta, Amato Laura Benedetta, Ceccarelli Claudio, Santini Donatella, Cormio Gennaro, Fracasso Flavio, Selvaggi Luigi, Resta Leonardo, Attimonelli Marcella, Gadaleta Maria Nicola, Gasparre Giuseppe
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations have been described in almost all types of cancer. However, their exact role and timing of occurrence during tumor development and progression are still a matter of debate. A Vogelstein-like model of progression is well established for endometrial carcinoma (EC), however, mtDNA has been scarcely investigated in these tumors despite the fact that mitochondrial biogenesis...
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