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Effect of zinc binding residues in growth hormone (GH) and altered intracellular zinc content on regulated GH secretion.

Endocrinology - 1 Nov 2013

Petkovic Vibor, Miletta Maria Consolata, Eblé Andrée, Iliev Daniel I, Binder Gerhard, Flück Christa E, Mullis Primus E

Abstract excerpt

Endocrine cells store hormones in concentrated forms (aggregates) in dense-core secretory granules that are released upon appropriate stimulation. Zn(2+) binding to GH through amino acid residues His18, His21, and Glu174 are essential for GH dimerization and might mediate its aggregation and storage in secretory granules. To investigate whether GH-1 gene mutations at these positions interfere with this process,...

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PMID: 23970781
DOI: 10.1210/en.2013-1089

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