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Article

In vitro analysis of hGH secretion in the presence of mutations of amino acids involved in zinc binding.

Journal of molecular endocrinology - 1 Aug 2007

Iliev Daniel I, Wittekindt Nicola E, Ranke Michael B, Binder Gerhard

Abstract excerpt

Zinc (Zn(2+)) binding by human GH through amino acid residues His18, His21, and Glu174 has been described as a prerequisite for GH dimerization and storage in secretory granules. Our aim was to investigate in vitro whether disturbed Zn(2+) binding of mutant GH inhibits wild-type GH (wtGH) secretion and contributes to the pathogenetic mechanisms involved in dominantly transmitted isolated GH deficiency type II....

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Identifiers

PMID: 17693614
DOI: 10.1677/JME-07-0039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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