Article
High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis.
Human molecular genetics - 1 Sept 2001
Barton A, Eyre S, Myerscough A, Brintnell B, Ward D, Ollier W E, Lorentzen J C, Klareskog L, Silman A, John S, Worthington J
Abstract excerpt
Rheumatoid arthritis (RA) is an oligogenic autoimmune disease but, to date, linkage and association to major histocompatibility complex (MHC) has been the only consistent finding in genetic studies. However, MHC is estimated to contribute only 30-40% of the total genetic component to disease susceptibility. Studies in animal models of inflammatory arthritis have identified a number of putative vulnerability loci...
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