Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.

Human molecular genetics - 1 Oct 2003

Scherzer Clemens R, Jensen Roderick V, Gullans Steven R, Feany Mel B

Abstract excerpt

Transgenic Drosophila expressing human alpha-synuclein faithfully replicate essential features of human Parkinson's disease, including age-dependent loss of dopaminergic neurons, Lewy-body-like inclusions and locomotor impairment. To define the transcriptional program encoding molecular machinery involved in alpha-synuclein pathology, we characterized expression of the entire Drosophila genome at pre-symptomatic,...

Topics

Join the communities discussing this publication.

alpha-Synuclein
Animals, Genetically Modified
Lewy Bodies
Nerve Degeneration
Parkinson Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12915459
DOI: 10.1093/hmg/ddg265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease.PMID 12915459Read ↗

Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson’s diseaseSemantic proximity Read ↗

A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease.Semantic proximity Read ↗

A new synuclein-transgenic mouse model for early Parkinson’s reveals molecular features of preclinical diseaseSemantic proximity Read ↗

Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivoSemantic proximity Read ↗

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.Semantic proximity Read ↗

Regulation of alpha-synuclein expression: implications for Parkinson's disease.Semantic proximity Read ↗

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease modelSemantic proximity Read ↗

Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathySemantic proximity Read ↗

Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.Semantic proximity Read ↗

Tau polarizes an aging transcriptional signature to excitatory neurons and gliaSemantic proximity Read ↗

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease.Semantic proximity Read ↗

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.