Article
The HLA class III subregion is responsible for an increased breast cancer risk.
Human molecular genetics - 15 Sept 2003
de Jong Mirjam M, Nolte Ilja M, de Vries Elisabeth G E, Schaapveld Michael, Kleibeuker Jan H, Oosterom Elvira, Oosterwijk Jan C, van der Hout Annemarie H, van der Steege Gerrit, Bruinenberg Marcel, Boezen H Marike, Te Meerman Gerard J, van der Graaf Winette T A
Abstract excerpt
BRCA1 and BRCA2 germline mutations account for <5% of breast cancer cases. Less penetrant breast cancer susceptibility genes are likely to exist. Earlier studies have suggested involvement of the HLA region. The HLA region was genotyped with 24 microsatellite markers and markers for two single nu...
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