Article
Relevance of the MHC region for breast cancer susceptibility in Asians.
Breast cancer (Tokyo, Japan) - 1 Sept 2022
Ho Peh Joo, Khng Alexis Jiaying, Tan Benita Kiat-Tee, Tan Ern Yu, Tan Su-Ming, Tan Veronique Kiak Mien, Lim Geok Hoon, Aronson Kristan J, Chan Tsun L, Choi Ji-Yeob, Dennis Joe, Ho Weang-Kee, Hou Ming-Feng, Ito Hidemi, Iwasaki Motoki, John Esther M, Kang Daehee, Kim Sung-Won, Kurian Allison W, Kwong Ava, Lophatananon Artitaya, Matsuo Keitaro, Mohd-Taib Nur Aishah, Muir Kenneth, Murphy Rachel A, Park Sue K, Shen Chen-Yang, Shu Xiao-Ou, Teo Soo Hwang, Wang Qin, Yamaji Taiki, Zheng Wei, Bolla Manjeet K, Dunning Alison M, Easton Douglas F, Pharoah Paul D P, Hartman Mikael, Li Jingmei
Abstract excerpt
BACKGROUND: Human leukocyte antigen (HLA) genes play critical roles in immune surveillance, an important defence against tumors. Imputing HLA genotypes from existing single-nucleotide polymorphism datasets is low-cost and efficient. We investigate the relevance of the major histocompatibility complex region in breast cancer susceptibility, using imputed class I and II HLA alleles, in 25,484 women of Asian...
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