Article

HLA gene polymorphism is a modifier of age-related breast cancer penetrance in carriers of BRCA1 pathogenic alleles

2024-01-31

Abstract excerpt

<title>Abstract</title> <p>Purpose Female carriers of germline <italic>BRCA1</italic> mutations almost invariably develop breast cancer (BC) however the age at onset is a subject of variation. We hypothesized that the age-related penetrance of <italic>BRCA1</italic> mutations may depend on inherited variability in the host immune system. Methods Next-generation sequencing was utilized for genotyping of HLA clas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75c923f8-e847-5cbb-893b-0cf25ee4f22a
DOI: 10.21203/rs.3.rs-3897419/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HLA gene polymorphism is a modifier of age-related breast cancer penetrance in carriers of BRCA1 pathogenic allelesDOI 10.21203/rs.3.rs-3897419/v1Read

HLA-DRB1,-DQA1 and -DQB1 allele and haplotype frequencies in female patients with early onset breast cancer.Semantic proximity Read

Damaging missense variants in innate immunity genes are associated with earlier age of breast cancer onset in BRCA1 185delAG carriers.Semantic proximity Read

Association of HLA-G +3142 C>G polymorphism and breast cancer in Tunisian population.Semantic proximity Read

Possible impact of HLA class I and class II on malignancies driven by a single germ-line BRCA1 mutation.Semantic proximity Read

Breast Cancer Is Associated with Increased HLA-DRB1*11:01 and HLA-DRB1*10:01 Allele Frequency in a Population of Patients from Central Italy.Semantic proximity Read

BRCA1 novel variation V1736D and in silico analysis of SNP Q356R in Sudanese patients with breast cancerSemantic proximity Read

Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage.Semantic proximity Read

Germline Pathogenic Variants in Breast Cancer-Predisposing Genes Among Early-Onset Female and Male Breast Cancer in Ethiopia.Semantic proximity Read

HLA class II variants in Chinese breast cancer patients.Semantic proximity Read

HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia?Semantic proximity Read

Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants – an Asian study of 572 familiesSemantic proximity Read

Relationship between HLA-DRB1 gene polymorphism and breast cancer: A protocol for systematic review and meta-analysis.Semantic proximity Read