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Article

Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog.

Science (New York, N.Y.) - 8 Aug 2003

Thibert Chantal, Teillet Marie-Aimée, Lapointe Françoise, Mazelin Laetitia, Le Douarin Nicole M, Mehlen Patrick

Abstract excerpt

During early development in vertebrates, Sonic hedgehog (Shh) is produced by the notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning of the neural tube. However, Shh is also required for the survival of neuroepithelial cells. We show that Patched (Ptc) in...

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Source

Identifiers

PMID: 12907805
DOI: 10.1126/science.1085405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12907805-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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