Article
The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis.
Development (Cambridge, England) - 1 Sept 1996
Bhat K M
Abstract excerpt
The Drosophila signaling molecule Wingless (Wg) plays crucial roles in cell-cell communications during development. In the developing nervous system, a previous study has shown that Wg acts non-autonomously to specify the fate of a specific neuronal precursor, NB4-2 (Q. Chu-LaGraff and C. Q. Doe (1993) Science 261, 1594-1597). The lack of autocrine specification of NB4-2 in Wg-expressing cells suggests that the...
Topics
- Animals
- Central Nervous System
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation, Developmental
- Genes, Insect
- Immunohistochemistry
- Insect Hormones
- Membrane Proteins
- Motor Neurons
- Mutation
- Phenotype
- Proto-Oncogene Proteins
- Receptors, Cell Surface
- Signal Transduction
- Wnt1 Protein