Article
A role for Rab27b in NF-E2-dependent pathways of platelet formation.
Blood - 1 Dec 2003
Tiwari Sanjay, Italiano Joseph E, Barral Duarte C, Mules Emilie H, Novak Edward K, Swank Richard T, Seabra Miguel C, Shivdasani Ramesh A
Abstract excerpt
Megakaryocytes release platelets by reorganizing the cytoplasm into proplatelet extensions. Fundamental to this process is the need to coordinate transport of products and organelles in the appropriate abundance to nascent platelets. The importance of the Rab family of small GTPases (guanosine 5'-triphosphatases) in platelet biogenesis is revealed in gunmetal (gm/gm) mice, which show deficient Rab isoprenylation...
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