Article
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2000
Detter J C, Zhang Q, Mules E H, Novak E K, Mishra V S, Li W, McMurtrie E B, Tchernev V T, Wallace M R, Seabra M C, Swank R T, Kingsmore S F
Abstract excerpt
Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and reduced platelet alpha- and delta-granule contents. Here we show by positional cloning that gm results from a G-->A substitution mutation in a splice acceptor site within the alpha-subunit of Rab geranylgeranyl transferase...
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