Article
Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes.
Haematologica - 1 Mar 2017
Beauchemin Hugues, Shooshtarizadeh Peiman, Vadnais Charles, Vassen Lothar, Pastore Yves D, Möröy Tarik
Abstract excerpt
Mutations in GFI1B are associated with inherited bleeding disorders called GFI1B-related thrombocytopenias. We show here that mice with a megakaryocyte-specific Gfi1b deletion exhibit a macrothrombocytopenic phenotype along a megakaryocytic dysplasia reminiscent of GFI1B-related thrombocytopenia. GFI1B deficiency increases megakaryocyte proliferation and affects their ploidy, but also abrogates their...
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