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Article

SNP genotyping using alkali cleavage of RNA/DNA chimeras and MALDI time-of-flight mass spectrometry.

Nucleic acids research - 9 Feb 2006

Mauger Florence, Jaunay Olivier, Chamblain Valérie, Reichert Fred, Bauer Keith, Gut Ivo G, Gelfand David H

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are now widely used for many DNA analysis applications such as linkage disequilibrium mapping, pharmacogenomics and traceability. Many methods for SNP genotyping exist with diverse strategies for allele-distinction. Mass spectrometers are used most commonly in conjunction with primer extension procedures with allele-specific termination. Here we present a novel concept for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 16473841
DOI: 10.1093/nar/gnj021
PMCID: PMC1369287

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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