Article
Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk.
Breast cancer research and treatment - 1 May 2006
Langsenlehner Uwe, Renner Wilfried, Yazdani-Biuki Babak, Eder Tanja, Wascher Thomas C, Paulweber Bernhard, Clar Heimo, Hofmann Günter, Samonigg Hellmut, Krippl Peter
Abstract excerpt
Integrins are cell surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Some of them, e.g. alpha(V)beta(3), alpha(IIb)beta(3) and alpha(2)beta(1), have been suggested as key players for cancer development and tumor metastasis. Two polymorphisms in the gene for the alpha(2) component, ITGA2 807C>T and 1648G>A, have been associated with the cell-surface density of integrin...
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