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Article

Integrin beta-3 genetic variants and risk of venous thromboembolism in colorectal cancer patients.

Thrombosis research - 1 Nov 2015

Bianconi Daniela, Schuler Alexandra, Pausz Clemens, Geroldinger Angelika, Kaider Alexandra, Lenz Heinz-Josef, Kornek Gabriela, Scheithauer Werner, Zielinski Christoph C, Pabinger Ingrid, Ay Cihan, Prager Gerald W

Abstract excerpt

BACKGROUND: Integrin β3 is involved in tumor and endothelial cell biology as well as in platelet aggregation. Herein, we evaluated the predictive potential of three germline single nucleotide polymorphisms (SNPs) in the integrin β3 gene (rs3809865, rs5918 and rs4642) to predict the risk of venous thromboembolism (VTE) in colorectal cancer (CRC) patients, which is one of the leading causes of death among cancer...

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Identifiers

PMID: 26440977
DOI: 10.1016/j.thromres.2015.08.010
PMCID: PMC7496222

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