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Article

Integrin genes and susceptibility to human melanoma.

Mutagenesis - 1 May 2012

Lenci Romina E, Rachakonda P Sivaramakrishna, Kubarenko Andriy V, Weber Alexander N R, Brandt Andreas, Gast Andreas, Sucker Antje, Hemminki Kari, Schadendorf Dirk, Kumar Rajiv

Abstract excerpt

Integrins are transmembrane adhesion molecules that mediate cell-cell and cell-extracellular matrix attachment. Integrins regulate cell growth, proliferation, migration and apoptosis and as a consequence, can have a potential role in tumour progression and metastasis. In this study, we investigated 19 non-synonymous variants in the coding region of the human integrin genes representing 3 beta subunits and 13...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22189006
DOI: 10.1093/mutage/ger090

Genes

ITGAE
ITGA2
ITGA10
ITGA6
ITGAM
ITGAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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