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Article

Roles for inhibitory interactions in the use of the -10 promoter element by sigma 70 holoenzyme.

The Journal of biological chemistry - 10 Oct 2003

Fenton Mike S, Gralla Jay D

Abstract excerpt

A panel of seven -10 region DNA mutants was tested for holoenzyme binding against a panel of 13 region 2 mutants of sigma 70. No patterns were noticed that would indicate unique interactions between individual amino acids and individual -10 region bases. Instead, certain amino acid substitutions led to increased holoenzyme binding to DNA, implying that the wild type interactions are associated with an inhibitory...

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Identifiers

PMID: 12902332
DOI: 10.1074/jbc.M307412200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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