Article

Ablation of <i>Ezh2</i> in neural crest cells leads to Hirschsprung's disease-like phenotype in mice

2018-02-15

Abstract excerpt

In the current study, we examined the role of Ezh2 as an epigenetic modifier for the enteric neural crest cell development through H3K27me3. Ezh2 conditional null mice were viable up to birth, but died within the first hour of life. In addition to craniofacial defects, Ezh2 conditional null mice displayed reduced number of ganglion cells in the enteric nervous system. RT-PCR and ChIP assays indicated aberrant u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8da04e42-321a-5e0b-a658-8210ee4997bf
DOI: 10.1101/265868

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ablation of <i>Ezh2</i> in neural crest cells leads to Hirschsprung's disease-like phenotype in miceDOI 10.1101/265868Read

Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in miceSemantic proximity Read

“Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a reviewSemantic proximity Read

Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system developmentSemantic proximity Read

Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during developmentSemantic proximity Read

Literature review: enteric nervous system development, genetic and epigenetic regulation in the etiology of Hirschsprung's diseaseSemantic proximity Read

The gastrointestinal development ‘parts list’: transcript profiling of embryonic gut development in wildtype and <i>Ret</i> -deficient miceSemantic proximity Read

Epigenetics in ENS development and Hirschsprung diseaseSemantic proximity Read

Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung diseaseSemantic proximity Read

Epigenetic Mechanisms in Hirschsprung DiseaseSemantic proximity Read

Gain and loss of function variants in EZH1 disrupt neurogenesis timing and cause overlapping neurodevelopmental disordersSemantic proximity Read

An integrative multi-omics framework identifies epigenetic dysregulation of <i>HAND2</i> as a potential primary driver of impaired enteric neural crest cell differentiation in Hirschsprung DiseaseSemantic proximity Read

Aebp2 as an Epigenetic Regulator for Neural Crest CellsSemantic proximity Read