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Article

Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Aug 2003

Das Biswadip, Butler J Scott, Sherman Fred

Abstract excerpt

A nuclear mRNA degradation (DRN) system was identified from analysis of mRNA turnover rates in nup116-Delta strains of Saccharomyces cerevisiae lacking the ability to export all RNAs, including poly(A) mRNAs, at the restrictive temperature. Northern blotting, in situ hybridization, and blocking transcription with thiolutin in nup116-delta strains revealed a rapid degradation of mRNAs in the nucleus that was...

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Identifiers

PMID: 12897126
DOI: 10.1128/MCB.23.16.5502-5515.2003
PMCID: PMC166345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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