Article
Mutant LYS2 mRNAs retained and degraded in the nucleus of Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2006
Das Biswadip, Das Satarupa, Sherman Fred
Abstract excerpt
We previously demonstrated that mRNAs retained in the nucleus of Saccharomyces cerevisiae are subjected to a degradation system-designated DRN (degradation of mRNA in the nucleus), that is diminished in cbc1-Delta or cbc2-Delta mutants lacking components of the cap-binding complex and in rrp6-Delta mutants lacking Rrp6p, a 3' to 5' nuclear exonuclease. Two mutants, lys2-187 and lys2-121, were uncovered by...
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