Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.

Genes & development - 1 Aug 2003

Lindblom Per, Gerhardt Holger, Liebner Stefan, Abramsson Alexandra, Enge Maria, Hellstrom Mats, Backstrom Gudrun, Fredriksson Simon, Landegren Ulf, Nystrom Henrik C, Bergstrom Goran, Dejana Elisabetta, Ostman Arne, Lindahl Per, Betsholtz Christer

Abstract excerpt

Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelial Growth Factors
Share to Glomerulosclerosis, Focal Segmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphokines

Share to Microcirculation

Share to Pericytes

Share to Platelet-Derived Growth Factor

Share to Proto-Oncogene Proteins c-sis

Share to Vascular Endothelial Growth Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 12897053
DOI: 10.1101/gad.266803
PMCID: PMC196228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.PMID 12897053Read ↗

Pericytes and the Pathogenesis of Diabetic RetinopathySemantic proximity Read ↗

Plastic roles of pericytes in the blood–retinal barrierSemantic proximity Read ↗

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.Semantic proximity Read ↗

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.Semantic proximity Read ↗

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1Semantic proximity Read ↗

Mild pericyte deficiency is associated with aberrant brain microvascular flow in aged PDGFRβ+/- mice.Semantic proximity Read ↗

R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.Semantic proximity Read ↗

Endothelial C-Type Natriuretic Peptide Acts on Pericytes to Regulate Microcirculatory Flow and Blood Pressure.Semantic proximity Read ↗

PDGF-B Is Required for Development of the Glymphatic SystemSemantic proximity Read ↗

Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in miceSemantic proximity Read ↗

Loss of endothelial barrier integrity in mice with conditional ablation of podocalyxin (Podxl) in endothelial cells.Semantic proximity Read ↗

What brings pericytes to tumor vessels?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.