Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.

Journal of vascular research - 1 Jan 2021

Herrera Jose Luis, Komatsu Masanobu

Abstract excerpt

PURPOSE: The retinal vasculature is heavily invested by pericytes. Small GTPase R-Ras is highly expressed in endothelial cells and pericytes, suggesting importance of this Ras homolog for the regulation of the blood vessel wall. We investigated the specific contribution of pericyte-expressed R-Ras to the development of the retinal vasculature. METHODS: The effect of R-Ras deficiency in pericytes was analyzed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Cadherins
Share to Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microphthalmos

Share to Neovascularization, Pathologic

Share to Pericytes

Share to Receptor, Platelet-Derived Growth Factor beta

Share to Retinal Vessels

Source

Open in PubMed Open full text

Identifiers

PMID: 33873190
DOI: 10.1159/000514555
PMCID: PMC8263468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

R-Ras Deficiency in Pericytes Causes Frequent Microphthalmia and Perturbs Retinal Vascular Development.PMID 33873190Read ↗

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1Semantic proximity Read ↗

Pericytes and the Pathogenesis of Diabetic RetinopathySemantic proximity Read ↗

Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae.Semantic proximity Read ↗

Plastic roles of pericytes in the blood–retinal barrierSemantic proximity Read ↗

Impaired pericyte recruitment and abnormal retinal angiogenesis as a result of angiopoietin-2 overexpressionSemantic proximity Read ↗

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytesSemantic proximity Read ↗

Mural cell SRF controls pericyte migration, vessel patterning and blood flowSemantic proximity Read ↗

Repeated treatment with VEGF receptor inhibitors induces phenotypic changes in endothelial cells and pericytes in the rat retina.Semantic proximity Read ↗

Mural cells protect the adult brain from hemorrhage but do not control the blood-brain barrier in developing zebrafishSemantic proximity Read ↗

Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.Semantic proximity Read ↗

Role of the Norrie Disease Pseudoglioma Gene in Sprouting Angiogenesis during Development of the Retinal VasculatureSemantic proximity Read ↗

Modeling ZNF408-Associated FEVR in Zebrafish Results in Abnormal Retinal VasculatureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.