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Article

Allelic association study between phospholipase A2 genes and bipolar affective disorder.

Bipolar disorders - 1 Aug 2003

Meira-Lima Ivanor, Jardim Daniela, Junqueira Ricardo, Ikenaga Elisa, Vallada Homero

Abstract excerpt

OBJECTIVES: In vivo studies demonstrating that lithium is a powerful phospholipase A2 (PLA2) inhibitor suggest that PLA2 activation, and subsequent cell signaling overactivation by increased fatty acid release may be the primary abnormality in bipolar affective disorder (BPAD), thus making PLA2 genes attractive candidates for the susceptibility to BPAD. The present study investigates polymorphisms in cytosolic...

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PMID: 12895207
DOI: 10.1034/j.1399-5618.2003.00025.x

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