Article
Polymorphism screening of PIK4CA: possible candidate gene for chromosome 22q11-linked psychiatric disorders.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2003
Saito Takuya, Stopkova Pavla, Diaz Libna, Papolos Demitri F, Boussemart Lise, Lachman Herbert M
Abstract excerpt
Lithium is potent non-competitive inhibitor of an enzyme involved in the metabolism of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P(2)), a critical phosphoinositide (PI) that regulates signal transduction and synaptic vesicle function. Interestingly, a number of genes involved in the regulation of PtdIns-4,5-P(2) synthesis and dephosphorylation are found in regions of the genome previously mapped in...
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