Article
No association of endocannabinoid genes with bipolar disorder or lithium response in a Sardinian sample.
Psychiatry research - 30 Dec 2013
Pisanu Claudia, Congiu Donatella, Costa Marta, Sestu Massimiliano, Chillotti Caterina, Ardau Raffaella, Deiana Valeria, Manchia Mirko, Squassina Alessio, Del Zompo Maria
Abstract excerpt
Bipolar disorder (BD) is a chronic and severe psychiatric condition with an underlying component of genetic susceptibility. Mounting evidence suggests a potential role of the endogenous cannabinoid (eCB) system in the pathogenesis of BD. Here we investigated the role of genes encoding for key eCB elements on the risk of developing BD in a sample of 357BD patients and 422 healthy controls of Sardinian ancestry....
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