Article
Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer.
Cancer letters - 30 Jul 2003
Maeno Kazuma, Ito Ken-ichi, Hama Yoshihisa, Shingu Kiyoshi, Kimura Morihiko, Sano Muneaki, Nakagomi Hiroshi, Tsuchiya Shin-ichi, Fujimori Minoru
Abstract excerpt
Mutation of the class I beta-tubulin gene has been reported to be one of the mechanisms that cause resistance to paclitaxel. To assess the relationship between paclitaxel-resistance and class I beta-tubulin gene mutation in breast cancer, Japanese patients with breast cancer were screened for the class I beta-tubulin gene mutation. Total RNA was isolated from 82 breast cancer specimens and the corresponding...
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