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Article

Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.

International journal of cancer - 15 May 2007

Tommasi Stefania, Mangia Anita, Lacalamita Rosanna, Bellizzi Antonia, Fedele Vita, Chiriatti Annalisa, Thomssen Christopher, Kendzierski Nancy, Latorre Agnese, Lorusso Vito, Schittulli Francesco, Zito Francesco, Kavallaris Maria, Paradiso Angelo

Abstract excerpt

The antineoplastic effect of paclitaxel is mainly related to its ability to bind the beta subunit of tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of the Class I beta-tubulin characteristics have also been confirmed in the clinical setting where mutations of paclitaxel-binding site of beta-tubulin Class I have been related to paclitaxel resistance in non small cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17285590
DOI: 10.1002/ijc.22557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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