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Article

Comparative Analysis of Mammalian Adaptive Immune Loci Revealed Spectacular Divergence and Common Genetic Patterns.

Molecular biology and evolution - 1 Jul 2025

Pospelova Mariia, Voss Katalin, Zamyatin Anton, Watson Corey T, Koepfli Klaus-Peter, Bankevich Anton, Pennell Matt, Safonova Yana

Abstract excerpt

Adaptive immune responses are mediated by the production of adaptive immune receptors, antibodies, and T-cell receptors, which bind antigens, thus causing their neutralization. Unlike other proteins, adaptive immune receptors are not fully encoded in the germline genome and result from a complex of somatic processes collectively called V(D)J recombination affecting germline immunoglobulin (IG) and T-cell receptor...

Read the complete abstract on PubMed

Topics

Animals
Mammals
Adaptive Immunity
Evolution, Molecular
Phylogeny
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Variation

Receptors, Antigen, T-Cell

Immunoglobulin Heavy Chains

Source

Open in PubMed Open full text

Identifiers

PMID: 40580934
DOI: 10.1093/molbev/msaf152
PMCID: PMC12288031

Genes

IGL
IGH
IGK
TRA
TRB

Provenance

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