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Article

Biochemical importance of glycosylation of plasminogen activator inhibitor-1.

Thrombosis and haemostasis - 1 Aug 2003

Gils Ann, Pedersen Katrine E, Skottrup Peter, Christensen Anni, Naessens Dominik, Deinum Johanna, Enghild Jan J, Declerck Paul J, Andreasen Peter A

Abstract excerpt

The serpin plasminogen activator inhibitor-1 (PAI-1) is a potential target for anti-thrombotic and anti-cancer therapy. PAI-1 has 3 potential sites for N-linked glycosylation. We demonstrate here that PAI-1 expressed recombinantly or naturally by human cell lines display a heterogeneous glycosylation pattern of the sites at N209 and N265, while that at N329 is not utilised. The IC(50)-values for inactivation of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 12888867
DOI: 10.1160/TH03-01-0034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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